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用途の概要

OCTは汎用性があり、医療・バイオ分野の多くの研究者や専門家が、さまざまなタイプの組織を非侵襲かつ非接触でイメージングするための手法として採用しています。この技術は、いくつかの分野においてはまだ理論的または実験的研究の段階ですが、他の分野ではその性能がすでに証明されています。

医療・バイオ分野で注目されるOCTの活用例

• 蝸牛殻
• 臓器細胞
• 皮膚
• 神経系
• 毛細血管系

Publications

Zhang W, Li Y, Nguyen VP, Huang Z, Liu Z, Wang X, Paulus YM. "High-resolution, in vivo multimodal photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy imaging of rabbit retinal neovascularization." Nature. 2018 December 5; 7: 103.

Nguyen VP, Li Y, Zhang W, Wang X, Paulus YM. "Multi-wavelength, en-face photoacoustic microscopy and optical coherence tomography imaging for early and selective detection of laser induced retinal vein occlusion." Biomedical Optics Express. 2018 December 1; 9(12): 5915-5938.

Capowski EE, Samimi K, Mayerl SJ, Phillips MJ, Pinilla I, Howden SE, Saha J, Jansen AD, Edwards KL, Jager LD, Barlow K, Valiauga R, Erlichman Z, Hagstrom A, Sinha D, Sluch VM, Chamling X, Zack DJ, Skala MC, Gamm DM. "Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines." Development. 2019 January 9; 146: dev171686.

Leite de Andrade MC, Soares de Oliveira MA, Graciano dos Santos FA, Vilela PBX, da Silva MN, Macêdo DPC, Neto RGL, Neves HJP, Brandão ISL, Chaves GM, de Araujo RE, Neves RP. "A new approach by optical coherence tomography for elucidating biofilm formation by emergent Candida species." Plos One. 2017 November 16; 12(11): e-188020.

Kerse C, Kalaycioglu H, Elahi P, Çetin B, Kesim DK, Akçaalan O, Yavas S, Asik MD, Öktem B, Hoogland H, Holzwarth R, Ilday FO. "Ablation-cooled material removal with ultrafast bursts of pulses." Nature. 2016 July 13; 537: 84-88.

Ahsen OO, Tao YK, Potsaid BM, Sheikine Y, Jiang J, Grulkowski I, Tsai T, Jayaraman V, Kraus MF, Connolly JL, Hornegger J, Cable A, Fujimoto JG. "Swept source optical coherence microscopy using a 1310 nm VCSEL light source." Optics Express. 2013 July 29; 21(15) 18021-18033.

Potsaid B; Jayaraman V; Fujimoto JG; Jiang J; Heim PJS; Cable AE. "MEMS tunable VCSEL light source for ultrahigh speed 60kHz - 1MHz axial scan rate and long range centimeter class OCT imaging." SPIE Proceedings. 2012 February 8; 8213.

Tsai T, Tao YK, Potsaid BM, Jayaraman V, Kraus MF, Heim PJS, Hornegger J, Mashimo H, Cable AE, Fujimoto JG. "Ultrahigh speed endoscopic optical coherence tomography using micro-motor imaging catheter and VCSEL technology." SPIE Proceedings. 2013 March 20; 8571.

Jayaraman V, Potsaid B, Jiang J, Cole GD, Robertson ME, Burgner CB, John DD, Grulkowski I, Choi W, Tsai TH, Liu J, Stein BA, Sanders ST, Fujimoto JG, Cable AE. "High-speed ultra-broad tuning MEMS-VCSELs for imaging and spectroscopy." SPIE Proceedings. 2013 May 17; 8763.

Tsai T, Potsaid B, Tao YK, Jayaraman V, Jiang J, Heim PJS, Kraus MF, Zhou C, Hornegger J, Mashimo H, Cable AE, Fujimoto JG. "Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology." Biomedical Optics Express. 2013 July 1; 4(7): 1119-1132.

Choi W, Potsaid B, Jayaraman V, Baumann B, Grulkowski I, Liu JJ, Lu CD, Cable AE, Huang D, Duker JS, Fujimoto JG. "Phase-sensitive swept-source optical coherence tomography imaging of the human retina with a vertical cavity surface-emitting laser light source." Optics Letters. 2013 February 1; 38(3): 338-340.

Li Q, Onozato ML, Andrews PM, Chen C, Paek A, Naphas R, Yuan S, Jiang J, Cable A, Chen Y. "Automated quantification of microstructural dimensions of the human kidney using optical coherence tomography (OCT)." Optics Express. 2009 August 31; 17(18): 16000-16016.

Chen Y, Aguirre AD, Ruvinskaya L, Devor A, Boas DA, Fujimoto JG. "Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation." Journal of Neuroscience Methods. 2009 March 30; 178(1): 162-173.

Yuan S, Li Q, Jiang J, Cable A, Chen Y. "Three-dimensional coregistered optical coherence tomography and line-scanning fluorescence laminar optical tomography." Optics Letters. 2009 June 1; 34(11): 1615-1617.

Andrews PM, Chen Y, Onozato ML, Huang S, Adler DC, Huber RA, Jiang J, Barry SE, Cable AE, Fujimoto JG. "High-resolution optical coherence tomography imaging of the living kidney." Laboratory Investigation. 2008 February 11; 88: 441-449.

Wen X, Jacques SL, Tuchin VV, Zhu D. "Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging." Journal of Biomedical Optics. 2012 June 13; 17(6): 066022.

Grulkowski I, Liu JJ, Potsaid B, Jayaraman V, Lu CD, Jiang J, Cable AE, Duker JS, Fujimoto JG. "Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers." Biomedical Optics Express. 2012 November 1; 3(11): 2733-2751.

Grulkowski I, Potsaid B, Liu JJ, Jayaraman V, Cable AE, Jiang J, Kraus MF, Hornegger J, Fujimoto JG. "Ophthalmic Applications of Ultrahigh Speed OCT Using VCSEL Light Source Technology." Investigative Ophthalmology & Visual Science. 2012 March; 53(14): 5258.

Grulkowski I, Liu JJ, Zhang JY, Potsaid B, Jayaraman V, Cable AE, Duker JS, Fujimoto JG. "Reproducibility of a Long-Range Swept-Source Optical Coherence Tomography Ocular Biometry System and Comparison with Clinical Biometers." American Academy of Ophthalmology. 2013 June 5; 120(11): 2184-2190.

Lu C, Kraus M, Grulkowski I, Liu J, Potsaid B, Jayaraman V, Cable A, Hornegger J, Duker J, Fujimoto J. "Handheld High Speed 500 kHz Swept Source OCT Device Using a Micro Scanning Mirror." Investigative Ophthalmology & Visual Science. 2013 June; 54(15): 1489.

Potsaid B, Liu J, Choi W, Grulkowski I, Jayaraman V, Jiang J, Heim P, Jay Duker J, Cable A, Fujimoto J. "VCSEL Laser Technology for Ultrahigh Speed and Extended Depth Range OCT Imaging of the Retina and Anterior Eye." Investigative Ophthalmology & Visual Science. 2013 June; 54(15): 1491.

Grulkowski I, Liu J, Potsaid B, Jayaraman V, Cable A, Kraus M, Hornegger J, Duker J, Huang D, Fujimoto J. "Three-Dimensional Biometric Measurements of Accommodation Using Full-Eye-Length Swept-Source OCT." Investigative Ophthalmology & Visual Science. 2013 June; 54(15): 381.

Dhalla A, Liu J, Mohler K, Potsaid B, Lu C, Jayaraman V, Cable A, Huang D, Fujimoto J. "Ultrahigh speed polarization sensitive OCT of the anterior and posterior eye using a 1050 nm VCSEL light source." Investigative Ophthalmology & Visual Science. 2013 June; 54(15): 1492.

Lu CD, Grulkowski I, Liu JJ, Kraus MF, Potsaid B, Jayaraman V, Cable A, Hornegger J, Duker JS, Fujimoto JG. "Handheld High Speed Swept Source Optical Coherence Tomography at 1050nm." 2012 March; 53(14): 2143.

Potsaid B, Gorczynska I, Srinivasan VJ, Chen Y, Jiang J, Cable A, Fujimoto JG. "Ultrahigh speed Spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second." Optics Express. 2008 September 15; 16(19): 15149-15169.

Srinivasan VJ, Huber R, Gorczynska I, Fujimoto JG, Jiang JY, Reisen P, Cable AE. "High-speed, high-resolution optical coherence tomography retinal imaging with a frequency-swept laser at 850 nm." Optics Letters. 2007 February 15; 32(4): 361-363.

Carolus AE, Lenz M, Hofmann M, Welp H, Schmieder K, Brenke C. "High-resolution in vivo imaging of peripheral nerves using optical coherence tomography: a feasibility study." Journal of Neurosurgery. 2019 April 26; 132(6): 1907-1913.

Argarini R, McLaughlin RA, Joseph SZ, Naylor LH, Carter HH, Yeap BB, Jansen SJ, Green DJ. "Optical coherence tomography: a novel imaging approach to visualize and quantify cutaneous microvascular structure and function in patients with diabetes." BMJ Open Diabetes Research & Care. 2020 August 26; 8: e001479.

Li X, Zhang W, Wang WY, Wu X, Li Y, Tan X, Matera DL, Baker BM, Paulus YM, Fan X, Wang X. "Optical coherence tomography and fluorescence microscopy dual-modality imaging for in vivo single-cell tracking with nanowire lasers." Biomedical Optics Express. 2020 July 1; 11(7): 3659-3672.

Zhang W, Li Y, Yu Y, Derouin K, Qin Y, Nguyen VP, Xiaobo X, Wang X, Paulus YM. "Simultaneous photoacoustic microscopy, spectral-domain optical coherence tomography, and fluorescein microscopy multi-modality retinal imaging." Photoacoustics. 2020 June 6; 20: 100194.

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用途の概要

OCTの使いやすさと非侵襲性により、歯科医療の分野でさまざまな用途に使用されています。以下に実例を示しますが、利用法はこれに限りません。

• さまざまな病変や異常の診断、修復、モニタ
• 修復物および修復物の欠陥の評価
• 歯肉検査

詳細についてはDentistry App Highlightをご覧ください。

Publications

Leiss-Holzinger E, Wiesauer K, Stephani H, Heise B, Stifter D, Kriechbaumer B, Spachinger SJ, Gusenbauer C, Withalm G. "Imaging of the inner structure of cave bear teeth by novel non-destructive techniques." Palaeontologia Electronica. 2015 January 21; 18.1.1T

Seidemannm MR, Haak R, Olms C. "Pilotuntersuchung zur Bewertung von Grenzflächen mittels OCT: Belastung einer Resin-Nano-Keramik auf einteiligen ZrO2-Implantaten." Deutscher Ärzteverlag . 2017; 33 (3): 202-211.

Schneider H, Park K, Hafer M, Ruger C, Schmalz G, Krause F, Schmidt J, Ziebolz D, Haak R. "Dental Applications of Optical Coherence Tomography (OCT) in Cariology." Appl. Sci.. 2017 May 3; 7(5) 472.

Park K, Schneider H, Haak R. "Assessment of interfacial defects at composite restorations by swept source optical coherence tomography." J. of Biomedical Optics. 2013 July 22; 18(7) 076018-1 - 076018-5.

Fernandes LO, Mota CCBO, Oliveira HO, Neves JK, Santiago LM, Gomes ASL. "Optical coherence tomography follow-up of patients treated from periodontal disease." J. Biophotonics. 2019 February; 12(2) e201800209.

Sahyoun CC, Subhash HM, Peru D, Ellwood R, Zaidel L, Kilpatrick L, Pierce MC. "Effect of Optical Coherence Tomography Resolution on the Assessment of Dental Enamel Indications." OSA Technical Digest (Optical Society of America, 2018). 2018 April 3-6;paper JTh3A.5.

S. Lee; et al. "Non-Ionized, High-Resolution Measurement of Internal and Marginal Discrepancies of Dental Prosthesis Using Optical Coherence Tomography." IEEE Access. 2018 December 24; 7 6209-6218.

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用途の概要

動物モデルを研究することで生物学的現象を理解し、その結果を人間生物学や医療に応用しようとしています。OCTはその使いやすさと非侵襲性により研究者にとって不可欠なツールとなっており、動物モデルをin-vivoでイメージングしたり、動物が成体になるまでの過程をイメージングしたりすることを可能にしています。詳細については Developmental Biology App Highlightをご覧ください。

Publications

Wangpraseurt D, Jacques S, Lyndby N, Holm JB, Pages CF, Kühl M. "Microscale light management and inherent optical properties of intact corals studied with optical coherence tomography." Journal of the Royal Society Interface. 2019 Feb 13; 16(151)

Marrese M, Antonovaite N, Nelemans BKA, Smit TH, Iannuzzi D. "Micro-indentation and optical coherence tomography for the mechanical characterization of embryos: Experimental setup and measurements on fixed chicken embryos." Acta Biomaterialia. 2019 Oct 1; 97 (1): 524-534.

Comanns P, Buchberger G, Buchsbaum A, Baumgartner R, Kogler A, Bauer S, Baumgartner W. "Directional, passive liquid transport: the Texas horned lizard as a model for a biomimetic ‘liquid diode’." Journal of the Royal Society Interface. 2015 Aug 6; 12(109).

Dutta R, Liba O, SoRelle ED, Winetraub Y, Ramani VC, Jeffrey SS, Sledge GW, de la Zerda A. "Real-Time Detection of Circulating Tumor Cells in Living Animals Using Functionalized Large Gold Nanorods." Nano Lett.. 2019 March 21; 19 (4): 2334-2342.

Larina IV, Sudheendran N, Mohamad Ghosn, Jiang J, Cable A, Larin KV, Dickinson ME. "Live imaging of blood flow in mammalian embryos using Doppler swept-source optical coherence tomography." J. of Biomedical Optics. 2008 Nov 1; 13(6): 060506.

Mariampillai A, Standish BA, Munce NR, Randall C, Liu G, Jiang JY, Cable AE, Vitkin IA, Yang VXD. " Doppler optical cardiogram gated 2D color flow imaging at 1000 fps and 4D in vivo visualization of embryonic heart at 45 fps on a swept source OCT system." Optics Express. 2007 February 19; 15(4): 1627-1638.

Davis AM, Rothenberg FG, Shepherd N, Izatt JA. "In vivo spectral domain optical coherence tomography volumetric imaging and spectral Doppler velocimetry of early stage embryonic chicken heart development." Journal of the Optical Society of America. 2008 December 1; 25(12): 3134-3143.

Davis A, Izatt JA, Rothenberg F. " Quantitative Measurement of Blood Flow Dynamics in Embryonic Vasculature Using Spectral Doppler Velocimetry." The Anatomical Record. 2009 Feb 26; 292(3): 311-319.

Jenkins SA, Porter TE. " Ontogeny of the hypothalamo–pituitary–adrenocortical axis in the chicken embryo: a review." Domestic Animal Endocrinology. 2004 May; 26(4): 267-275.

K. Courchaine, M.J. Gray, K. Beel, K. Thornburg, S. Rugonyi. " 4-D Computational Modeling of Cardiac Outflow Tract Hemodynamics over Looping Developmental Stages in Chicken Embryos." J. Cardiovasc. Dev. Dis.. 2019 Feb 27; 6 (1): 11.

M.J. Wolf. " 3D imaging of a beating fly heart (upper center) using optical coherence tomography, a technique similar to echocardiography." Duke Today. 2015 February 3.

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用途の概要

光コヒーレンスエラストグラフィでは、ドップラー光コヒーレンストモグラフィ(OCT)を用いて生体組織の弾性を定量化し、印加応力の関数として局所的な組織の変位を測定します。詳細についてはElastography App Highlightをご覧ください。

Publications

Hepburn MS, Wijesinghe P, Chin L, Kennedy BF. "Analysis of spatial resolution in phase-sensitive compression optical coherence elastography." Biomedical Optics Express. 2019; 10(3): 1496-1513.

Kennedy KM, Ford C, Kennedy BF, Bush MB, Sampson DD. "Analysis of mechanical contrast in optical coherence elastography." Journal of Biomedical Optics. 2013 November 12; 18(12): 121508.

Moon S, Chen Z. "Phase-stability optimization of swept-source optical coherence tomography." Biomedical Optics Express. 2018; 9(11): 5280-5295.

Krajancich B, Curatolo A, Fang Q, Zilkens R, Dessauvagie BF, Saunders CM, Kennedy BF. "Handheld optical palpation of turbid tissue with motion-artifact correction." Biomedical Optics Express. 2019; 10(1): 226-241.

Es’haghian S, Kennedy KM, Gong P, Li Q, Chin L, Wijesinghe P, Sampson DD, McLaughlin RA, Kennedy BF. "In vivo volumetric quantitative microelastography of human skin." Biomedical Optics Express. 2017; 8(5): 2458-2471.

Nebelung S, Brill N, Müller F, Tingart M, Pufe T, Merhof D, Schmitt R, Jahr H, Truhn D. "Towards Optical Coherence Tomography-based elastographic evaluation of human cartilage." Journal of the Mechanical Behavior of Biomedical Materials. 2016 March; 56: 106-119.

Düwel D, Otte C, Schulz K, Saatho T, Schlaefer A. "Towards contactless optical coherence elastography with acoustic tissue excitation." Current Directions in Biomedical Engineering. 2015 September 12; 1(1): 215-219.

Allen WM, Kennedy KM, Fang Q, Chin L, Curatolo A, Watts L, Zilkens R, Chin SL, Dessauvagie BF, Latham B, Saunders CM, Kennedy BF. "Wide-field quantitative micro-elastography of human breast tissue." Biomedical Optics Express. 2018; 9(3): 1082-1096.

Es'haghian S, Gong P, Chin L, Harms KA, Murray A, Rea S, Kennedy BF, Wood FM, Sampson DD, McLaughlin RA. "Investigation of optical attenuation imaging using optical coherence tomography for monitoring of scars undergoing fractional laser treatment." Journal of Biophotonics. 2017 April; 10(4): 511-522.

Jonas S, Bhattacharya D, Khokha MK, Choma MA. "Microfluidic characterization of cilia-driven fluid flow using optical coherence tomography-based particle tracking velocimetry." Biomedical Optics Express. 2011; 2(7): 2022-2034.

Kataja M, Haavisto S, Salmela J, Lehto R, Koponen A. "Characterization of micro-fibrillated cellulose fiber suspension flow using multi scale velocity profile measurements." Nordic Pulp & Paper Research Journal. 2018 July 19; 32(3): 473-482.

Meeuw H, Korbelin J, von Bernstorff D, Augustin T, Liebig WV, Fiedler B. "Smart dispersion: Validation of OCT and impedance spectroscopy as solutions for in-situ dispersion analysis of CNP/EP-composites." Materialia. 2018; 1: 185-197.

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用途の概要

産業分野においては、OCTはある種の試料や製品の特性を非破壊・非接触で評価するのに優れたツールであることがすでに証明されています。用途の範囲は膜厚測定から欠陥や粒子の検出、形状パラメータの評価や制御にまで及びます。OCTは、初期のR&D、プロトタイプ作成、最終製品の評価、単一ユニットの品質管理など、生産ライフサイクルのすべての段階で活用できます。産業分野におけるOCTの活用例

• ディスプレイ
• 製薬
• コンタクトレンズの計測
• パッケージング
• 工業用塗料およびニス
• 薄膜
• CAD/CAM
• 3Dプリント
• 複合材料
• 航空宇宙
• 溶接およびキーホールのマッピング
• 肉の品質管理

詳細についてはOCT Displays App Highlightをご覧ください。

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用途の概要

OCTは2次元イメージングを介して蝸牛内の特定の構造の位置を決定し、その位置における振動データ(振幅および位相シフト)を取得することができるため、聴覚のメカニズムを理解するための強力な技術となっています。この情報を用いて、医学研究者は聴覚器官の機能障害や異常を分析し、将来の治療法の向上に役立てることができます。詳細についてはVibrometry App Highlightをご覧ください。

Publications

Cooper NP, Vavakou A, van der Heijden M. "Vibration hotspots reveal longitudinal funneling of sound-evoked motion in the mammalian cochlea." Nature Communications. 2018 August 3; 9: 3054.

Nuttall AL, Ricci AJ, Burwood G, Harte JM, Stenfelt S, Cayé-Thomasen P, Ren T, Ramamoorthy S, Zhang Y, Wilson T, Lunner T, Moore BCJ, Fridberger A. "A mechanoelectrical mechanism for detection of sound envelopes in the hearing organ." Nature Communications. 2018 October 9; 9: 4175.

Ton Y, Sakamoto T, Nakagawa T, Adachi T, Taniguchi M, Torii H, Hamaguchi K, Kitajiri S, Ito J. "In Vivo Imaging of Mouse Cochlea by Optical Coherence Tomography." Otology & Neurology. 2014 February; 35(2): e84-89.

Lin NC, Fallah E, Strimbu CE, Hendon CP, Olson ES. "Scanning optical coherence tomography probe for in vivo imaging and displacement measurements in the cochlea." Biomedical Optics Express. 2019 February 1; 10(2): 1032-1043.

Ling WA, Ellerbee AK. "The effects of reduced bit depth on optical coherence tomography phase data." Optics Express. 2012 July 2; 20(14): 15654-15668.

Pau HW, Lankenau E, Just T, Behrend D, Hüttmann G. "Optical coherence tomography as an orientation guide in cochlear implant surgery?" Acta Oto-Laryngologica. 2009 July 8; 127(9): 907-913.

Vavakou A, Cooper NP, van der Heijden M. "The frequency limit of outer hair cell motility measured in vivo." eLife. 2019 September 24; 8: e47667.